STEM-PD trial protocol: a multi-centre, single-arm, first-in-human, dose-escalation trial, investigating the safety and tolerability of intraputamenal transplantation of human embryonic stem cell-derived dopaminergic cells for Parkinson’s disease
Gesine Paul, Hjalmar Bjartmarz, Anders Björklund, Emma Cutting, Amy Evans, Bronwen Harry, Oskar Hansson, Saeed Kayhanian, Agnete Kirkeby, Nicholas Lao-Kim, Olle Lindvall, Jenny Nelander, Paola Piccini, Ruben Smith, Susann Ullén, Trinette Van Vliet, Hakan Widner, Malin Parmar, Roger A Barker · 2025
Read STEM-PD trial protocol: a multi-centre, single-arm, first-in-human, dose-escalation trial, investigating the safety and tolerability of intraputamenal transplantation of human embryonic stem cell-derived dopaminergic cells for Parkinson’s disease by Gesine Paul, Hjalmar Bjartmarz, Anders Björklund, Emma Cutting, Amy Evans, Bronwen Harry, Oskar Hansson, Saeed Kayhanian, Agnete Kirkeby, Nicholas Lao-Kim, Olle Lindvall, Jenny Nelander, Paola Piccini, Ruben Smith, Susann Ullén, Trinette Van Vliet, Hakan Widner, Malin Parmar, Roger A Barker (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12766818.txt.
Description
Gesine Paul and a large team set out a first-in-human cell transplant trial for Parkinson's in a 2025 protocol. The disease kills the midbrain cells that make a key brain chemical, which drives slow moves and stiff limbs. Grafts of such cells have been tried for years, first from unborn tissue.
Their trial plants lab-grown cells, bred from human stem stock, into the brain's putamen in rising doses. Many centers run one shared arm, with safety and bearability as the marks. A sound pass would open the path to wider tests of cell grafts.
Catalog record
| CREATOR | Gesine Paul, Hjalmar Bjartmarz, Anders Björklund, Emma Cutting, Amy Evans, Bronwen Harry, Oskar Hansson, Saeed Kayhanian, Agnete Kirkeby, Nicholas Lao-Kim, Olle Lindvall, Jenny Nelander, Paola Piccini, Ruben Smith, Susann Ullén, Trinette Van Vliet, Hakan Widner, Malin Parmar, Roger A Barker |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |