Flow Cytometric Profiling of Peripheral Immune Checkpoints Predicts Prognosis and Reveals PD-1/Treg/IL-10 Crosstalk in B-Cell Lymphoma
Bing Pan, Sijia Li, Ruyu Ye, Jie Zhu, Yawei Tang, Li Li · 2025
Read Flow Cytometric Profiling of Peripheral Immune Checkpoints Predicts Prognosis and Reveals PD-1/Treg/IL-10 Crosstalk in B-Cell Lymphoma by Bing Pan, Sijia Li, Ruyu Ye, Jie Zhu, Yawei Tang, Li Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12766162.txt.
Description
Bing Pan, Sijia Li, Ruyu Ye, Jie Zhu, Yawei Tang, and Li Li published a 2025 study of immune checkpoints in the blood of patients with B-cell lymphoma. Immune checkpoints are molecules that restrain immune cells. Their significance in this blood cancer, both as warning signs and as working parts of the disease, was underexplored.
The team analyzed blood from 140 patients using flow cytometry, which counts immune cells by their surface markers. They measured PD-1, CTLA-4, LAG-3, and TIM-3 on T cells, and compared levels by disease aggressiveness, spread beyond lymph nodes, and treatment response. They also studied crosstalk between PD-1, regulatory T cells, and the signaling molecule IL-10. The profiles predicted prognosis, suggesting a blood test could help forecast the disease's course.
Catalog record
| CREATOR | Bing Pan, Sijia Li, Ruyu Ye, Jie Zhu, Yawei Tang, Li Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |