Single-Cell Sequencing Uncovers a TMSB10-Expressing Fibroblast Subpopulation Driving Renal Fibrosis in Diabetic Nephropathy
Zihan Qin, Xiaoli Huang, Ke Du, Liexiang Zhang, Xiaohong Xu, Yuepeng Fang · 2025
Read Single-Cell Sequencing Uncovers a TMSB10-Expressing Fibroblast Subpopulation Driving Renal Fibrosis in Diabetic Nephropathy by Zihan Qin, Xiaoli Huang, Ke Du, Liexiang Zhang, Xiaohong Xu, Yuepeng Fang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12765935.txt.
Description
Zihan Qin and co-authors use single cell gene reading to find cells that drive kidney scarring in diabetic kidney disease in a 2025 study. The disease is a leading cause of end stage kidney failure, and scarring is its core damage, yet the cells behind the scarring are not fully mapped. The team reanalyzed public data from human kidneys.
They found a group of fibroblast cells, high in a gene called TMSB10, much expanded in diseased kidneys. Those cells were rich in genes for scar material and for a known scar signal path. Lowering the gene in lab cells and in diabetic mice cut scar markers by about half or more and reduced scar build up.
Catalog record
| CREATOR | Zihan Qin, Xiaoli Huang, Ke Du, Liexiang Zhang, Xiaohong Xu, Yuepeng Fang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |