Rictor/mTORC2 signaling pathway mediates Benzo[a]pyrene-induced renal injury
Jian-Qiu Han, Ying Qu, Yuan-rong Zhu, Ya-Lei Qi, Teng-Fei Liu, Yong-Mei Li, Yan-Jia Zhang, Juan Tan, Hong-hui Han, Xue-Yun Ma · 2025
Read Rictor/mTORC2 signaling pathway mediates Benzo[a]pyrene-induced renal injury by Jian-Qiu Han, Ying Qu, Yuan-rong Zhu, Ya-Lei Qi, Teng-Fei Liu, Yong-Mei Li, Yan-Jia Zhang, Juan Tan, Hong-hui Han, Xue-Yun Ma (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12765000.txt.
Description
Jian-Qiu Han and co-authors trace how a common pollutant injures kidneys through a growth signaling pathway, in a 2025 study. The pollutant is benzo[a]pyrene, a persistent chemical from smoke and char. It is a known kidney toxin. The team gave mice a single large oral dose. Kidney injury markers rose within three days. Antioxidant defenses fell at the same time. Later, inflammation and cell death took over.
A pathway built around a protein called Rictor switched on during the later phase. Its downstream partners rose in step. To test its role, the team used mice lacking the protein in immune macrophages. Those mice showed less oxidative stress after exposure. Inflammatory release and cell death also dropped. The authors name the pathway a possible drug target. Blocking it might protect kidneys after pollutant exposure. The study is the first to pin this pathway to the injury.
Catalog record
| CREATOR | Jian-Qiu Han, Ying Qu, Yuan-rong Zhu, Ya-Lei Qi, Teng-Fei Liu, Yong-Mei Li, Yan-Jia Zhang, Juan Tan, Hong-hui Han, Xue-Yun Ma |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |