RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination
Michael Gruet, Yitao Xu, Lyutong An, Yurui Ma, Cristina Balcells, Katie Tyson, Laila C. Evangelista, Sarah Spear, Yuewei Xu, Flora McKinney, Julia Babuta, Chandler Bray, Chiharu Wickremesinghe, Alexandros P. Siskos, Anke M. Nijhuis, Edward W. Tate, Iain A. McNeish, Adrian Benito, Hector C. Keun · 2025
Read RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination by Michael Gruet, Yitao Xu, Lyutong An, Yurui Ma, Cristina Balcells, Katie Tyson, Laila C. Evangelista, Sarah Spear, Yuewei Xu, Flora McKinney, Julia Babuta, Chandler Bray, Chiharu Wickremesinghe, Alexandros P. Siskos, Anke M. Nijhuis, Edward W. Tate, Iain A. McNeish, Adrian Benito, Hector C. Keun (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12764903.txt.
Description
Michael Gruet leads a team that found a gene pattern marking ovarian cancer cells that a two-drug mix can kill, in a study published in two thousand twenty-five. The mix pairs a PARP blocker with a drug that cuts a cell fuel called NAD. The second drug has been hard to dose safely, so a marker for who benefits most is key. The team screened a panel of ovarian cancer cell lines.
Cells with faults in the RAS and PI3K growth paths proved most sensitive. The drug pair drained the fuel, raised cell stress, and drove the mutant cells to die. In mice, the pair shrank tumors seeded near the belly organs and lengthened life. The authors say the gene pattern could pick patients for this mix.
Catalog record
| CREATOR | Michael Gruet, Yitao Xu, Lyutong An, Yurui Ma, Cristina Balcells, Katie Tyson, Laila C. Evangelista, Sarah Spear, Yuewei Xu, Flora McKinney, Julia Babuta, Chandler Bray, Chiharu Wickremesinghe, Alexandros P. Siskos, Anke M. Nijhuis, Edward W. Tate, Iain A. McNeish, Adrian Benito, Hector C. Keun |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |