Immune and metabolic signatures characterise constipation-driven endophenotypes in Parkinson’s disease
Abbey Figliomeni, Samantha Winter, Madison Abonnel, Jade Kenna, Samantha Lodge, Luke Whiley, Andres Bernal, Jerome D. Coudert, Jonathan Noonan, Belinda Kaskow, Ryan Anderton · 2025
Read Immune and metabolic signatures characterise constipation-driven endophenotypes in Parkinson’s disease by Abbey Figliomeni, Samantha Winter, Madison Abonnel, Jade Kenna, Samantha Lodge, Luke Whiley, Andres Bernal, Jerome D. Coudert, Jonathan Noonan, Belinda Kaskow, Ryan Anderton (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12764879.txt.
Description
Abbey Figliomeni and co-authors profile the gut and immune signatures of Parkinson's disease, focusing on patients troubled by constipation. Digestive problems are the most common early non-motor symptom of the disease, and some evidence suggests the illness may begin in the gut. The team compared thirty-one patients with twenty-eight healthy controls.
Stool and blood samples revealed shifted chemistry: several energy-related compounds fell in stool while others rose in blood. Immune profiling showed fewer T cells, more natural killer cells, and B cells tilted toward memory types, with the shifts tracking a metabolite called succinate. Sorting the blood data split the patients into two subtypes. One carried stronger gut symptoms and T cell patterns pointing to travel between gut and brain. The authors say these paired immune and metabolic signatures define meaningful subgroups within Parkinson's.
Catalog record
| CREATOR | Abbey Figliomeni, Samantha Winter, Madison Abonnel, Jade Kenna, Samantha Lodge, Luke Whiley, Andres Bernal, Jerome D. Coudert, Jonathan Noonan, Belinda Kaskow, Ryan Anderton |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |