Divergent oncogenic signaling and immune microenvironment changes in low-grade serous ovarian cancer patients undergoing intraperitoneal chemotherapy
Isaac Bishara, Patrick A. Cosgrove, Sumana Majumdar, Colt A. Egelston, Oscar Colunga Flores, Brad Nakamura, Nora Ruel, Paul H. Frankel, Susan E. Yost, Sue Chang, Alexander Jung, Mihaela Cristea, Mustafa Raoof, Andrea H. Bild, Aritro Nath, Thanh H. Dellinger · 2025
Read Divergent oncogenic signaling and immune microenvironment changes in low-grade serous ovarian cancer patients undergoing intraperitoneal chemotherapy by Isaac Bishara, Patrick A. Cosgrove, Sumana Majumdar, Colt A. Egelston, Oscar Colunga Flores, Brad Nakamura, Nora Ruel, Paul H. Frankel, Susan E. Yost, Sue Chang, Alexander Jung, Mihaela Cristea, Mustafa Raoof, Andrea H. Bild, Aritro Nath, Thanh H. Dellinger (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12764849.txt.
Description
Isaac Bishara and co-authors track how a rare ovarian cancer shifts as patients get drug mist sprayed inside the belly in a 2025 study. The form of cancer spreads through the belly and often resists standard care. The spray method lets doctors take tumor samples again and again during care.
The team read single cells from samples of two patients, one who gained from care and one who did not. The tumor that resisted turned up growth and stress paths. The tumor that responded turned those paths down but woke other routes to stay alive. Immune cells also looked more held back in the resistant case. Even from two patients, the split shows why one plan fails some.
Catalog record
| CREATOR | Isaac Bishara, Patrick A. Cosgrove, Sumana Majumdar, Colt A. Egelston, Oscar Colunga Flores, Brad Nakamura, Nora Ruel, Paul H. Frankel, Susan E. Yost, Sue Chang, Alexander Jung, Mihaela Cristea, Mustafa Raoof, Andrea H. Bild, Aritro Nath, Thanh H. Dellinger |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |