Targeting TRAF3IP2 disrupts cellular energetics through inhibition of NAMPT in triple negative breast cancer
Kurtis Willingham, Amin Izadpanah, Yasmine Rashad, Antonia Reilich, Fatemeh Daneshimehr, Steven Braun, Eckhard U Alt, Reza Izadpanah · 2025
Read Targeting TRAF3IP2 disrupts cellular energetics through inhibition of NAMPT in triple negative breast cancer by Kurtis Willingham, Amin Izadpanah, Yasmine Rashad, Antonia Reilich, Fatemeh Daneshimehr, Steven Braun, Eckhard U Alt, Reza Izadpanah (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12764808.txt.
Description
Willingham and colleagues probe a weak spot in triple-negative breast cancer in this study from twenty twenty-five. This cancer grows fast and resists many drugs, in part by rewiring how it makes energy. The team focused on a protein called TRAF3IP2, which they had earlier linked to tumor growth, and on NAMPT, an enzyme the cell needs to recycle a key energy carrier.
Blocking TRAF3IP2 cut NAMPT levels and lowered the cell's stores of NAD and ATP. Two cancer models reacted in unlike ways, one leaning less on sugar burning and the other on its power plants, which shows how varied this cancer can be. The block also disturbed growth signals and raised harmful oxygen byproducts, so cells lived less and died more. The authors name TRAF3IP2 a possible drug target for this hard-to-treat cancer.
Catalog record
| CREATOR | Kurtis Willingham, Amin Izadpanah, Yasmine Rashad, Antonia Reilich, Fatemeh Daneshimehr, Steven Braun, Eckhard U Alt, Reza Izadpanah |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |