Quantitative assessment of innate myeloid cells in myelofibrosis: insights into myeloid and plasmacytoid dendritic cell depletion and disease progression
Nathália Aparecida Cavalcante Silva, Fábio Pinotti Guirao, Míriam Cristina Rodrigues Barbosa, Diego Alonso Olavarría Bernal, Laura Coutinho Vassalli, Alex Freire Sandes · 2025
Read Quantitative assessment of innate myeloid cells in myelofibrosis: insights into myeloid and plasmacytoid dendritic cell depletion and disease progression by Nathália Aparecida Cavalcante Silva, Fábio Pinotti Guirao, Míriam Cristina Rodrigues Barbosa, Diego Alonso Olavarría Bernal, Laura Coutinho Vassalli, Alex Freire Sandes (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12764507.txt.
Description
Nathalia Silva and co-authors counted immune guard cells in people with myelofibrosis, a bone marrow disease that scars the marrow. Their 2025 study drew blood from twenty-one patients at a Brazilian university and twelve healthy adults. The team focused on two kinds of dendritic cells and on monocyte groups.
Patients had far fewer of both dendritic cell kinds than healthy adults. The drop in one kind was steepest in patients with heavy scarring, low blood counts, and a swollen spleen. Monocyte shares changed little overall, though one group ran higher in patients with a common gene change. The authors say these cells may mark how far the disease has gone.
Catalog record
| CREATOR | Nathália Aparecida Cavalcante Silva, Fábio Pinotti Guirao, Míriam Cristina Rodrigues Barbosa, Diego Alonso Olavarría Bernal, Laura Coutinho Vassalli, Alex Freire Sandes |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |