Marmelosin Protects Against Metabolic Disturbances in High-Fat Diet and Streptozotocin-Induced Diabetes
Sattam Khulaif Alenezi, Khalid S Alharbi, Tariq G Alsahli, Reem ALQahtani, Muhammad Afzal, Krishana Kumar Sharma, Nadeem Sayyed · 2025
Read Marmelosin Protects Against Metabolic Disturbances in High-Fat Diet and Streptozotocin-Induced Diabetes by Sattam Khulaif Alenezi, Khalid S Alharbi, Tariq G Alsahli, Reem ALQahtani, Muhammad Afzal, Krishana Kumar Sharma, Nadeem Sayyed (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12764349.txt.
Description
Sattam Khulaif Alenezi and co-authors tested a plant compound, marmelosin, against diabetes in rats, in a 2025 study. Type 2 diabetes brings high blood sugar and wide metabolic strain, and standard drugs carry side effects that push interest toward natural options. Twenty-four rats were split into four groups for twenty-eight days. One group stayed healthy. One was made diabetic by a fat diet plus a pancreas-harming drug. The last two diabetic groups got low or higher oral doses of the compound.
Treated rats showed lower fasting glucose and lower long-term sugar markers, with more insulin and better insulin sensitivity. Blood fats improved, antioxidant defenses rose, and inflammatory signals fell. A cell-death protein also dropped, hinting at protection for tissues. The authors call marmelosin a multi-sided candidate for diabetes care, while the work remains at the rat stage.
Catalog record
| CREATOR | Sattam Khulaif Alenezi, Khalid S Alharbi, Tariq G Alsahli, Reem ALQahtani, Muhammad Afzal, Krishana Kumar Sharma, Nadeem Sayyed |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |