Plant Exosome-Loaded Intelligent Hydrogels for Osteoporotic Bone Regeneration: Mechanisms and Applications
Lang Li, Cong Ye, Zhong-qing Wu, Rong Wu · 2025
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Description
Osteoporotic bone heals poorly because its metabolism is off balance, its blood supply thin, and its surroundings inflamed, and Lang Li and co-authors review a plant-based delivery strategy. Tiny vesicles shed by plants carry regulatory RNAs, fats, and proteins that can coax bone formation, calm bone-eating cells, grow blood vessels, and ease inflammation. Smart hydrogels that answer to heat, acidity, or light can hold those vesicles and release them on schedule at a defect site.
The review covers vesicle biology, gel design, and the pair's combined effects in early studies. Translation hurdles include factory-scale vesicle production and sparse long-term animal data.
Catalog record
| CREATOR | Lang Li, Cong Ye, Zhong-qing Wu, Rong Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |