Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis
Marta Mazur, Artnora Ndokaj, Claudia Salerno, Jessica Vallone, Roman Ardan, Sabina Bietolini, Florence Carrouel, Aleksandra Wilk, Rachel Sarig, Livia Ottolenghi, Denis Bourgeois · 2025
Read Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis by Marta Mazur, Artnora Ndokaj, Claudia Salerno, Jessica Vallone, Roman Ardan, Sabina Bietolini, Florence Carrouel, Aleksandra Wilk, Rachel Sarig, Livia Ottolenghi, Denis Bourgeois (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12757266.txt.
Description
Vitamin B12 shots are the classic fix for low B12, and a 2025 review by Marta Mazur and co-authors asks whether pills or under-tongue doses work as well. Low B12 is common in older people, in those whose guts absorb poorly, and in people on plant-based diets.
The team searched three databases through July 2024 and pooled sixteen studies with 6,098 people in all. Trials, cohort studies, and case-control studies all counted. The pooled results compare how each route raised blood B12 and lowered homocysteine, a linked marker. Side analyses split the results by route, daily dose, age, and health conditions that change B12 handling. The review gives patients and doctors an evidence base for skipping the needle.
Catalog record
| CREATOR | Marta Mazur, Artnora Ndokaj, Claudia Salerno, Jessica Vallone, Roman Ardan, Sabina Bietolini, Florence Carrouel, Aleksandra Wilk, Rachel Sarig, Livia Ottolenghi, Denis Bourgeois |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |