From Single Ligand–Receptor Bond Strength to Collective Avidity: Mechanics-Guided Superselective Nanoparticle Adhesion to Biological Membranes
Morteza Hamzeh, Saba Mirahsani, Fatemeh Ahmadpoor, Samaneh Farokhirad · 2025
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Description
Morteza Hamzeh, Saba Mirahsani, Fatemeh Ahmadpoor, and Samaneh Farokhirad study how a nanoparticle's stiffness governs its grip on a cell membrane. Their 2025 paper concerns targeted nanomedicine, where particles coated with ligands latch onto receptors. The classic trade-off says many weak bonds can beat few strong ones for selectivity, yet how the particle's own mechanics tune that trade-off was unclear.
Computer simulations joined with thermodynamic analysis swept bond strength, receptor density, and membrane tension for rigid, semirigid, and bendable particles. Bendable ones won at middling bond strength, reshaping to recruit nearly every receptor even when receptors were scarce, at a real entropy cost. Semirigid ones needed the strongest bonds to pay their way. Rigid ones never used more than about a tenth of their ligands. Raising membrane tension hurt the stiff kinds but barely touched the bendable ones. The team maps design windows for selective adhesion.
Catalog record
| CREATOR | Morteza Hamzeh, Saba Mirahsani, Fatemeh Ahmadpoor, Samaneh Farokhirad |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |