Females with obesity exhibit greater influenza vaccine-induced immunity and protection than males in a mouse model
Brian Wolfe, Saurav Pantha, Saranya Vijayakumar, Shristy Budha Magar, Tawfik Aboellail, Santosh Dhakal · 2025
Read Females with obesity exhibit greater influenza vaccine-induced immunity and protection than males in a mouse model by Brian Wolfe, Saurav Pantha, Saranya Vijayakumar, Shristy Budha Magar, Tawfik Aboellail, Santosh Dhakal (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12756896.txt.
Description
Brian Wolfe and co-authors found obese female mice beat males after flu vaccine in two thousand twenty-five. Obesity blunts flu vaccine protection in people. Sex differences in that blunting were little studied. Mice were fattened on a high-fat diet. Both sexes got two shots of inactivated flu vaccine. Antibody and immune cell responses were measured after.
Obese females mounted stronger vaccine immunity overall. They also survived flu challenge better than obese males. Lean control groups framed the comparison. B and T cell readouts backed the survival gap. Sex thus shapes vaccine value under obesity. Human studies should stratify by sex and weight together. One-size vaccine policy may miss real differences.
Catalog record
| CREATOR | Brian Wolfe, Saurav Pantha, Saranya Vijayakumar, Shristy Budha Magar, Tawfik Aboellail, Santosh Dhakal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |