Clinical efficacy and mechanisms of transcutaneous auricular vagus nerve stimulation targeting the gut-brain axis for postoperative complications of aortic dissection: study protocol for a randomized controlled trial
Bo Ning, Liangbin Yang, Yi Wei, Cheng Luo, Feisheng Zheng, Teng Ge, Haining Ou, Chaojie Wang, Jinlin Hu, Qingzuo Zhao, Jingyu Bo, Kai Wang, Zhan Zhang, Hongyu Chen, Rongjun Zou, Xiaoping Fan, Jihai Peng · 2025
Read Clinical efficacy and mechanisms of transcutaneous auricular vagus nerve stimulation targeting the gut-brain axis for postoperative complications of aortic dissection: study protocol for a randomized controlled trial by Bo Ning, Liangbin Yang, Yi Wei, Cheng Luo, Feisheng Zheng, Teng Ge, Haining Ou, Chaojie Wang, Jinlin Hu, Qingzuo Zhao, Jingyu Bo, Kai Wang, Zhan Zhang, Hongyu Chen, Rongjun Zou, Xiaoping Fan, Jihai Peng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12756893.txt.
Description
Bo Ning and sixteen co-authors lay out a randomized trial protocol testing ear-based vagus nerve stimulation after dissection surgery, in a paper from twenty twenty-five. Aortic dissection is a life-threatening crisis with a high death rate. Surgery lifts short-term survival but often brings problems. These include systemic inflammation, gut dysfunction, and anxiety or depression, made worse by gut-brain axis upset.
The single-center trial will enroll fifty patients aged eighteen to seventy-five after surgery for type A or B dissection. Half receive active stimulation of the vagus-innervated ear area; half receive a sham treatment, with the team blinded. Both groups get standard care after surgery. The stimulation is non-invasive, known for anti-inflammatory and gut-motility effects elsewhere. Its use after such surgery is untested. The trial will judge how well it works, its safety, and gut-brain paths.
Catalog record
| CREATOR | Bo Ning, Liangbin Yang, Yi Wei, Cheng Luo, Feisheng Zheng, Teng Ge, Haining Ou, Chaojie Wang, Jinlin Hu, Qingzuo Zhao, Jingyu Bo, Kai Wang, Zhan Zhang, Hongyu Chen, Rongjun Zou, Xiaoping Fan, Jihai Peng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |