Identification of novel therapeutic targets and effective anticancer agents for gallbladder cancer by integrating bioinformatics analysis and experimental validation
Yanjie Zhong, Ruiqi Zou, Ximei Luo, Siqi Yang, Zhiqiang He, Haijie Hu, Fuyu Li · 2025
Read Identification of novel therapeutic targets and effective anticancer agents for gallbladder cancer by integrating bioinformatics analysis and experimental validation by Yanjie Zhong, Ruiqi Zou, Ximei Luo, Siqi Yang, Zhiqiang He, Haijie Hu, Fuyu Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12756669.txt.
Description
Zhong and six co-authors hunt new drug targets and agents for gallbladder and bile tract cancers, in a study from twenty twenty-five. Most patients respond poorly to existing therapies. Genetic randomization links druggable genes to cancer risk causally. Candidate drugs are then docked and tested in cells and organoids.
Eight genes associate with bile tract tumors in the analysis. Two, NT5E and C4B, stand out as network hubs. A plant compound, myricetin, binds NT5E strongly and validates experimentally. One target concentrates in a T cell type tied to immune evasion. The pipeline raises the odds of clinical success.
Catalog record
| CREATOR | Yanjie Zhong, Ruiqi Zou, Ximei Luo, Siqi Yang, Zhiqiang He, Haijie Hu, Fuyu Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |