Bromhexine hydrochloride enhances the therapeutic efficacy of tiamulin against experimental Staphylococcus aureus infection in dogs: targeting bacterial virulence, boosting antioxidant defense, and improving histopathology
Hanem F. El-Gendy, Shimaa R. Masoud, Nagwa I. Sheraiba, Shimaa S. Elnahriry, Doaa A. Madkour, Reda M. S. Korany, Hazim O. Khalifa, Hanaa Y. Elnagar · 2025
Read Bromhexine hydrochloride enhances the therapeutic efficacy of tiamulin against experimental Staphylococcus aureus infection in dogs: targeting bacterial virulence, boosting antioxidant defense, and improving histopathology by Hanem F. El-Gendy, Shimaa R. Masoud, Nagwa I. Sheraiba, Shimaa S. Elnahriry, Doaa A. Madkour, Reda M. S. Korany, Hazim O. Khalifa, Hanaa Y. Elnagar (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12756443.txt.
Description
A staph germ that floods a dog's body can damage many organs at once, driven by its toxins and by stress on cells. Hanem El-Gendy and seven co-authors test whether a mucus-thinning drug can boost a standard antibiotic against that germ. Their 2025 study works in dogs with a lab-raised infection.
Five groups split the dogs: healthy, infected and untreated, and three treated sets. One set got the antibiotic alone, one got the thinner alone, and one got both. The team reads stress markers in blood, germ counts in tissue, and gene marks tied to the germ's attack and to the heart. Tissue slices show the harm or its repair. The pair's joint score is the heart of the test.
Catalog record
| CREATOR | Hanem F. El-Gendy, Shimaa R. Masoud, Nagwa I. Sheraiba, Shimaa S. Elnahriry, Doaa A. Madkour, Reda M. S. Korany, Hazim O. Khalifa, Hanaa Y. Elnagar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |