The role of immune cells-mediated memory in weight cycling, glucose disorders and insulin resistance
Yiding Chen, Dongqi Zhou, Lan Wang, Lisha Sun, Yun Yin, Guo Liu, Changyan Zi · 2025
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Description
Yiding Chen and co-authors review how immune memory may drive weight cycling in a 2025 paper. Weight cycling means losing weight and gaining it back, again and again. Most people who lose weight regain it within a few years, and the pattern is tied to a higher risk of sugar and metabolism disorders.
The review argues that immune cells keep a memory of past weight gain, and that this memory shapes how the body handles fat and sugar later. Cells discussed include macrophages, several kinds of T cells, and a group of monocytes marked CD7. The authors link this memory to insulin resistance, where the body stops responding well to insulin. They also list possible treatments that would target the immune memory itself to help keep weight off.
Catalog record
| CREATOR | Yiding Chen, Dongqi Zhou, Lan Wang, Lisha Sun, Yun Yin, Guo Liu, Changyan Zi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |