Effect of prior therapy on the clinical activity of imetelstat in patients with transfusion-dependent, ESA-relapsed or -refractory/-ineligible LR-MDS
Rami S Komrokji, Valeria Santini, Amer M Zeidan, Mikkael A Sekeres, Pierre Fenaux, Azra Raza, Moshe Mittelman, Sylvain Thépot, Rena Buckstein, Ulrich Germing, Yazan F Madanat, María Díez-Campelo, David Valcárcel, Anna Jonášová, Souria Dougherty, Sheetal Shah, Qi Xia, Libo Sun, Shyamala Navada, Faye · 2025
Read Effect of prior therapy on the clinical activity of imetelstat in patients with transfusion-dependent, ESA-relapsed or -refractory/-ineligible LR-MDS by Rami S Komrokji, Valeria Santini, Amer M Zeidan, Mikkael A Sekeres, Pierre Fenaux, Azra Raza, Moshe Mittelman, Sylvain Thépot, Rena Buckstein, Ulrich Germing, Yazan F Madanat, María Díez-Campelo, David Valcárcel, Anna Jonášová, Souria Dougherty, Sheetal Shah, Qi Xia, Libo Sun, Shyamala Navada, Faye (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12756333.txt.
Description
A research team asks whether earlier treatments change how a new drug works in lower risk myelodysplastic syndromes in this 2025 paper. In this blood disorder the marrow makes faulty cells, anemia dominates, and many patients depend on red cell transfusions after standard hormone-like drugs fail or cannot be used.
The drug under study is imetelstat, a targeted therapy aimed at the disease process itself rather than only supporting blood counts. The analysis weighs the drug's clinical activity against each patient's prior therapy history. Patients whose disease has relapsed after, resisted, or ruled out the first line drugs have the fewest options. Knowing whether past treatment blunts the new drug matters for their care.
Catalog record
| CREATOR | Rami S Komrokji, Valeria Santini, Amer M Zeidan, Mikkael A Sekeres, Pierre Fenaux, Azra Raza, Moshe Mittelman, Sylvain Thépot, Rena Buckstein, Ulrich Germing, Yazan F Madanat, María Díez-Campelo, David Valcárcel, Anna Jonášová, Souria Dougherty, Sheetal Shah, Qi Xia, Libo Sun, Shyamala Navada, Faye |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |