Immuno-acoustic trapping for extracellular vesicle subpopulations
Axel Broman, Megan Havers, Roman Sattarov, Thomas Laurell · 2025
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Description
Axel Broman, Megan Havers, Roman Sattarov, and Thomas Laurell present a faster way to fish specific tiny parcels out of blood plasma. Their 2025 paper works with extracellular vesicles, small bubbles that cells shed, carrying proteins that can signal disease. Vesicles vary widely, and isolating one subgroup can reveal markers from a specific cell type.
Their method joins sound-based trapping with antibody-coated beads on an automated platform. In eight minutes, from a droplet of plasma, it yields two fractions: sound-trapped vesicles and those bound to beads targeting one surface marker. Protein profiling showed the bead fraction was enriched for that marker, beating a ninety-minute manual method.
Catalog record
| CREATOR | Axel Broman, Megan Havers, Roman Sattarov, Thomas Laurell |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |