Multiple-Dose Up-Titration Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Omecamtiv Mecarbil in Healthy Chinese Subjects
Xuening Li, Hui Li, Hongrong Xu, Fei Yuan, Hanjing Chen, Chao Liu, Mengjie Yang, Jing Li, Lei Sheng · 2025
Read Multiple-Dose Up-Titration Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Omecamtiv Mecarbil in Healthy Chinese Subjects by Xuening Li, Hui Li, Hongrong Xu, Fei Yuan, Hanjing Chen, Chao Liu, Mengjie Yang, Jing Li, Lei Sheng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12756200.txt.
Description
Xuening Li and co-authors step a heart drug up in dose in fifty sound adults in China to map its path through the body, in a study from 2025. The drug prods heart muscle to grip with more force, a rare tack for weak hearts. Two dose rounds rose from a low base to one of two higher marks, with a dummy drug arm for scale.
Blood marks show the drug clears in about a day and stacks near five fold with twice a day use. Dose steps lift blood load in even step, with no dose tied trend in harms. No grave harms struck in any arm. Mild flags were a muscle blood mark, high blood sugar, and slow pulse. Terms held as sound at all dose marks.
Catalog record
| CREATOR | Xuening Li, Hui Li, Hongrong Xu, Fei Yuan, Hanjing Chen, Chao Liu, Mengjie Yang, Jing Li, Lei Sheng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |