Anti-inflammatory effect of a pimarane diterpenoid isolated from Nepeta adenophyta Hedge based on a network analysis approach and experimental assessment
Wei Zhao, Meng Li, Chuanqing Jia, Iftikhar Ali, Long Chen · 2025
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Description
Wei Zhao and co-authors test a plant compound for calming inflammation, in a 2025 study. The source plant is a folk medicine in Pakistan used for belly pain, kidney pain, and headaches. One compound from the plant, from a family known to fight inflammation, was isolated in pure form for testing.
Computer network analysis first pointed to two pathways that the compound may act through. Lab tests on immune cells then showed lower levels of several inflammation signals after treatment. A key switch protein moved less into the cell nucleus, and two enzymes tied to inflammation fell. The authors read the results as support for a calming effect, reached through more than one route. Further work would be needed to test the compound in animals.
Catalog record
| CREATOR | Wei Zhao, Meng Li, Chuanqing Jia, Iftikhar Ali, Long Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |