Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions
Jiahuan Gong, Xingxing Fang, Xinlei Yao, Fei Xue, Guangdong Qi, Bingqian Chen, Hualin Sun · 2025
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Description
Jiahuan Gong and co-authors review the mechanisms of diabetic kidney disease and the new multi-target treatments for it, in a review paper from 2025. The disease is now the leading cause of end-stage kidney failure worldwide. Its drivers mix sugar damage, oxidation, inflammation, and scarring pathways.
Standard care slows the disease with blood pressure drugs that block the renin-angiotensin system, but it cannot undo scarring. Newer options include SGLT2 inhibitors, which ease pressure inside the kidney filter, and anti-inflammatory drugs that block scarring signals. The review also covers herbal multi-target formulas, nano-scale drug delivery, stem cells, and gene editing. The authors urge better early markers and multi-omics work to sort patient subtypes.
Catalog record
| CREATOR | Jiahuan Gong, Xingxing Fang, Xinlei Yao, Fei Xue, Guangdong Qi, Bingqian Chen, Hualin Sun |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |