Emerging roles for interleukin-11 in the inflammatory response of intracerebral hemorrhage
Letian Xue, Junrou Zhu, Haiyang Wang, Zheng Wang, Wenhua Yu · 2025
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Description
A bleed inside the brain is among the worst kinds of stroke, and the swelling that follows can do as much harm as the bleed itself. Letian Xue and four co-authors review a signal protein, interleukin-11, that has drawn fresh interest in that swelling. Their 2025 survey gathers what is known of its role after such a bleed.
Levels of the protein shift after a bleed, and it helps steer immune cell action, the release of other signals, and the tightness of the blood-brain wall. It also talks with many other swelling agents, which makes its net effect hard to read. Some signs hint it may shield nerve cells as well. The review lays out those paths and asks whether drugs that target the protein could aid recovery.
Catalog record
| CREATOR | Letian Xue, Junrou Zhu, Haiyang Wang, Zheng Wang, Wenhua Yu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |