JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease
Yunpo Zhao, Jianli Duan, Hannah Seah, Joyce van de Leemput, Zhe Han, Ilse S Daehn, Yunpo Zhao, Jianli Duan, Hannah Seah, Joyce van de Leemput, Zhe Han · 2025
Read JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease by Yunpo Zhao, Jianli Duan, Hannah Seah, Joyce van de Leemput, Zhe Han, Ilse S Daehn, Yunpo Zhao, Jianli Duan, Hannah Seah, Joyce van de Leemput, Zhe Han (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12755883.txt.
Description
A fat-rich diet can wreck the kidney's filter cells, and a fruit fly can stand in for a mammal in tracing how. Zhao and co-authors use that fly model in 2025 to show a chain from fat tissue to filter cell. The fly's filter cells match, in job, the cells that guard the human kidney's filters.
On the rich diet, the filter's fine slits break down and its sieving work fades. A signal path in the cells switches on. That path is lit by a hormone-like factor freed from the fat body, a leptin-like signal. Blocking the path, by genes or by drugs, restores the cells' work. The chain names a lever that past work had tied to diabetic kidney disease, here in a diet-driven form.
Catalog record
| CREATOR | Yunpo Zhao, Jianli Duan, Hannah Seah, Joyce van de Leemput, Zhe Han, Ilse S Daehn, Yunpo Zhao, Jianli Duan, Hannah Seah, Joyce van de Leemput, Zhe Han |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |