Exploring differential production of alkaloids and terpenoids in Cristataspora coffeata (Berk:) Robledo (Ganodermataceae) under submerged culture
Ricardo A. González-Hernández, Rodrigo Villanueva-Silva, C. Andrés Arganis-Ramírez, Norma A. Valdez-Cruz, Mauricio A. Trujillo-Roldán · 2025
Read Exploring differential production of alkaloids and terpenoids in Cristataspora coffeata (Berk:) Robledo (Ganodermataceae) under submerged culture by Ricardo A. González-Hernández, Rodrigo Villanueva-Silva, C. Andrés Arganis-Ramírez, Norma A. Valdez-Cruz, Mauricio A. Trujillo-Roldán (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12755829.txt.
Description
Ricardo González-Hernández and co-authors grew in 2025 a tropical fungus in liquid culture to see how its menu changes its chemistry. The fungus, Cristataspora coffeata, belongs to a family famed for drug-like compounds, especially terpenoids and alkaloids. Liquid culture beats fruiting bodies for control and scale. Two sugars, glucose and lactose, were compared as the carbon source.
Growth speed matched on both sugars, though pellets grew larger on glucose. The chemistry diverged clearly. Glucose cultures produced different sets of compounds in the flesh and in the broth at two time points. Chemical profiling counted dozens of differing compounds between the sugar regimes. The authors conclude the carbon source is a dial for steering output. Producers hunting one target molecule should pick the sugar that favors it.
Catalog record
| CREATOR | Ricardo A. González-Hernández, Rodrigo Villanueva-Silva, C. Andrés Arganis-Ramírez, Norma A. Valdez-Cruz, Mauricio A. Trujillo-Roldán |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |