The early human interferon gamma response to Toxoplasma gondii is driven by Vγ9Vδ2 T-cell sensing of host phosphoantigens and subsequent NK-cell activation
Felipe Rodriguez, Jeroen P. J. Saeij · 2025
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Description
Felipe Rodriguez and Jeroen Saeij published a 2025 study on how the human body first fights the parasite Toxoplasma gondii. The parasite infects tens of millions of people in the United States alone. Mice rely on defense tools that humans do not have, so the early human response was poorly understood.
Working with human blood cells, the pair found that a special group of T cells senses infected cells through a receptor called BTN3A1. These T cells release signals that switch on natural killer cells, which then make more of the defense protein interferon gamma. Blocking the pathway that makes the sensed molecules weakened the response. The findings name a clear first line of defense in people.
Catalog record
| CREATOR | Felipe Rodriguez, Jeroen P. J. Saeij |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |