Hesperidin alleviated D-GalN/LPS induced acute liver injury in mice: insights into gut microbiota and the Nrf2/Keap1 pathway
Kaiming Li, Gaohuan Hou, Hongbin Deng, Weiting Lu, Hongyou Liu, Weiqin Li, Qi Wang, Zhihui Tong · 2025
Read Hesperidin alleviated D-GalN/LPS induced acute liver injury in mice: insights into gut microbiota and the Nrf2/Keap1 pathway by Kaiming Li, Gaohuan Hou, Hongbin Deng, Weiting Lu, Hongyou Liu, Weiqin Li, Qi Wang, Zhihui Tong (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12755240.txt.
Description
Kaiming Li and co-authors published a research paper in 2025 on hesperidin, a citrus compound, easing sudden liver injury in mice, with gut microbes in the frame. A drug-plus-bacterial-toxin injection is a standard way to model acute liver failure. Forty mice were split among control, injury, and hesperidin groups, with tissue, blood, and gut contents sampled.
Hesperidin normalized liver enzyme leaks, cooled inflammation in liver and gut, and repaired the intestinal barrier. It switched on a master antioxidant pathway in the liver. Gut sequencing showed the microbial community shifting alongside the protection. The authors propose that the compound guards the liver partly by rebalancing the gut and its signals.
Catalog record
| CREATOR | Kaiming Li, Gaohuan Hou, Hongbin Deng, Weiting Lu, Hongyou Liu, Weiqin Li, Qi Wang, Zhihui Tong |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |