The placental effects of trisomy for human chromosome 21 orthologs in four mouse models of Down syndrome
Taisuke Sato, Laura L Baxter, April D Adams, Lauren A Bishop, Faycal Guedj, Diana W Bianchi · 2025
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Description
Down syndrome arises from an extra copy of human chromosome 21, and its effects on development begin before birth, when the placenta feeds the fetus and exchanges gases. Sato and co-authors compared placentas across four mouse models of the condition, each carrying extra copies of different sets of the matching mouse genes. They measured gene and protein levels in the placenta to see which genes the extra copies push up and what changes follow.
A few genes, including App, Sod1, and Ifnar1, rose in several models, and staining showed where in the tissue the rises occurred. Despite limited overlap between models, all four shared changes in pathways for the tissue scaffold around cells, and all showed disturbed handling of oxidation. Immune pathways rose in two models. The authors offer the work as a base for understanding how the extra chromosome affects the placenta and early development.
Catalog record
| CREATOR | Taisuke Sato, Laura L Baxter, April D Adams, Lauren A Bishop, Faycal Guedj, Diana W Bianchi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |