Astrocytic SIRT1 ameliorates cognitive deficits after traumatic brain injury via autophagy-mediated MEGF10 phagocytosis
Qianxin Ji, Yan Zhang, Zhuo Zhang, Kun Cui, Liang Zhao, Xiaoyu Sun, Huiling Qu, Jia Song, Jianru Xiao, Xiaobin Zhang, Yu Lu, Jianan Xu, Dan Li · 2025
Read Astrocytic SIRT1 ameliorates cognitive deficits after traumatic brain injury via autophagy-mediated MEGF10 phagocytosis by Qianxin Ji, Yan Zhang, Zhuo Zhang, Kun Cui, Liang Zhao, Xiaoyu Sun, Huiling Qu, Jia Song, Jianru Xiao, Xiaobin Zhang, Yu Lu, Jianan Xu, Dan Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12755027.txt.
Description
Qianxin Ji and co-authors present a 2025 study of a star cell protein that may guard thought after brain injury. Head trauma often leaves lasting memory and thinking harm. Star shaped support cells can turn too reactive after injury and start eating synapses, the links thought rides on.
One guard protein fell after injury in the memory hub and cortex. Boosting it in star cells sped the cells' own waste cleanup. That cleanup chewed up a surface tag that orders synapse eating, so fewer links were lost. When the cleanup gene was cut in star cells, the guard effect died with it. Human samples and mouse models both feed the claim. The path names a fresh drug aim for injury care.
Catalog record
| CREATOR | Qianxin Ji, Yan Zhang, Zhuo Zhang, Kun Cui, Liang Zhao, Xiaoyu Sun, Huiling Qu, Jia Song, Jianru Xiao, Xiaobin Zhang, Yu Lu, Jianan Xu, Dan Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |