Per- and polyfluoroalkyl substances (PFAS) exposure and cardiovascular risk: lipid profile as a mediator
Xianghai Wang, Yongping Cao, Xuli Chen, Guojin Jian, Fei Ma, Hengyang Zhang, Qiuyu Wang, Wenwen Xiao · 2025
Read Per- and polyfluoroalkyl substances (PFAS) exposure and cardiovascular risk: lipid profile as a mediator by Xianghai Wang, Yongping Cao, Xuli Chen, Guojin Jian, Fei Ma, Hengyang Zhang, Qiuyu Wang, Wenwen Xiao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12754923.txt.
Description
Xianghai Wang and seven colleagues test whether blood lipids carry the heart risk of forever chemicals, in a study published in two thousand twenty-five. PFAS compounds are being phased out in long-chain forms, but their true relationship to cardiovascular disease remains unsettled. Lipids are the suspected middleman.
Over twenty-five thousand American survey participants from twenty fifteen to twenty twenty contributed data. Individual compounds and their mixtures were modeled against disease and lipid measures with several advanced methods, including mixture regressions and causal mediation. Nonlinear dose patterns were checked. Mediation analysis quantifies how much of any PFAS effect travels through cholesterol changes. That decomposition matters for regulation: blocking a mediator differs from banning an exposure.
Catalog record
| CREATOR | Xianghai Wang, Yongping Cao, Xuli Chen, Guojin Jian, Fei Ma, Hengyang Zhang, Qiuyu Wang, Wenwen Xiao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |