Association of immune relevant single nucleotide polymorphisms with ALK-positive anaplastic large cell lymphoma presentation and outcome: results of the immuno ALCL study
Petrazzuolo Adriana, Vincent Carbonnier, Fatima Domenica Elisa De Palma, Maria Perez-Lanzon, Véronique Vergé, Cyril Quivoron, Laurence Lamant, Laurence Brugieres, Charlotte Rigaud, Stéphane Ducassou, Marie-Emilie Dourthe, Marie-Cécile Le Deley, Christine Damm-Welk, Willi Woessmann, Véronique Minard- · 2025
Read Association of immune relevant single nucleotide polymorphisms with ALK-positive anaplastic large cell lymphoma presentation and outcome: results of the immuno ALCL study by Petrazzuolo Adriana, Vincent Carbonnier, Fatima Domenica Elisa De Palma, Maria Perez-Lanzon, Véronique Vergé, Cyril Quivoron, Laurence Lamant, Laurence Brugieres, Charlotte Rigaud, Stéphane Ducassou, Marie-Emilie Dourthe, Marie-Cécile Le Deley, Christine Damm-Welk, Willi Woessmann, Véronique Minard- (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12754919.txt.
Description
Adriana Petrazzuolo and a large team ask whether inherited immune variants shape a rare lymphoma’s course, in a 2025 study. The lymphoma strikes mostly young people and is driven by a gene called ALK. Small inherited differences in cancer-immunity genes may set how well the body watches for the tumor, and thus how the disease presents and ends.
The Immuno ALCL study enrolled 180 patients and read 14 variants across 13 immunity genes. The team set those variants against age at diagnosis, survival without progression, tumor subtype, and each patient’s antibody response to ALK. Any firm link would help doctors sort patients by risk at diagnosis and could hint at immune treatments worth trying first.
Catalog record
| CREATOR | Petrazzuolo Adriana, Vincent Carbonnier, Fatima Domenica Elisa De Palma, Maria Perez-Lanzon, Véronique Vergé, Cyril Quivoron, Laurence Lamant, Laurence Brugieres, Charlotte Rigaud, Stéphane Ducassou, Marie-Emilie Dourthe, Marie-Cécile Le Deley, Christine Damm-Welk, Willi Woessmann, Véronique Minard- |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |