Accelerating epigenetic age in right-sided colon cancer predicts a favorable outcome
Qin Ye, Ping Song, Wangxiong Hu, Gangzhi Zhang · 2025
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Description
Qin Ye, Ping Song, Wangxiong Hu, and Gangzhi Zhang compare the DNA-based age of colon tumors on the left and right sides, in a 2025 study. A tumor's epigenetic age, read from chemical tags on DNA, can run ahead of or behind a patient's real age. Whether that gap links to tumor side and to survival was unclear.
They measure tag-based age in 548 samples with four clock models. Right-sided tumors read older than left-sided ones, though healthy tissue showed no such split. The age gap was widest in women and in one unstable tumor type on the right. As right-sided tumors advanced in stage, their tag age fell, while left-sided ones followed another path. Most striking, a fast-running clock meant better survival on the right but worse on the left, which marks the clock as a two-faced signal.
Catalog record
| CREATOR | Qin Ye, Ping Song, Wangxiong Hu, Gangzhi Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |