Development of a vaccine construct against Pneumocystis jirovecii pneumonia using computational tools
Ragini Mishra, Nahid Akhtar, Jorge Samuel Leon Magdeleno, Abdul Rajjak Shaikh, Manik Prabhu Narsing Rao, Neeta Raj Sharma, Luigi Cavallo, Mohit Chawla · 2025
Read Development of a vaccine construct against Pneumocystis jirovecii pneumonia using computational tools by Ragini Mishra, Nahid Akhtar, Jorge Samuel Leon Magdeleno, Abdul Rajjak Shaikh, Manik Prabhu Narsing Rao, Neeta Raj Sharma, Luigi Cavallo, Mohit Chawla (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12754782.txt.
Description
Eight researchers present a study from two thousand twenty-five designing a vaccine on a computer against a lung infection. The infection is pneumocystis pneumonia, caused by a fungus that threatens people with weak immune systems. No vaccine exists yet, so a designed candidate could fill a real gap.
The team scanned a surface protein of the fungus for fragments the immune system can recognize. Software checks filtered the fragments for safety and for their power to rouse immune defenses. Ten fragments passed and were linked with helper compounds into one construct. Docking and motion simulations then tested how the construct grips immune sensors.
Catalog record
| CREATOR | Ragini Mishra, Nahid Akhtar, Jorge Samuel Leon Magdeleno, Abdul Rajjak Shaikh, Manik Prabhu Narsing Rao, Neeta Raj Sharma, Luigi Cavallo, Mohit Chawla |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |