Cis‐2‐decenoic acid modulates Pseudomonas aeruginosa virulence through a noncanonical transcriptional regulator
Shihao Song, Jingyun Liu, Bing Wang, Yang Si, Hongguang Han, Xiuyun Sun, Mingfang Wang, Binbin Cui, Guangliang Wu, Yongliang Huo, Liangxiong Xu, Beile Gao, Liang Yang, Xiaoxue Wang, Lian‐Hui Zhang, Yinyue Deng · 2025
Read Cis‐2‐decenoic acid modulates Pseudomonas aeruginosa virulence through a noncanonical transcriptional regulator by Shihao Song, Jingyun Liu, Bing Wang, Yang Si, Hongguang Han, Xiuyun Sun, Mingfang Wang, Binbin Cui, Guangliang Wu, Yongliang Huo, Liangxiong Xu, Beile Gao, Liang Yang, Xiaoxue Wang, Lian‐Hui Zhang, Yinyue Deng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12754631.txt.
Description
Shihao Song and seventeen co-authors uncover a new quorum-sensing circuit in a lung pathogen. Their 2025 paper studies Pseudomonas aeruginosa and a fatty signal it releases. The signal, cis-2-decenoic acid, was known to scatter biofilms. How it steers the cell's genes stayed unclear.
The signal binds FadD1, an enzyme that normally handles fatty acids. Bound FadD1 grips gene switches more tightly, turning many genes up or down. The enzyme thus moonlights as a global regulator. It also acts on a cousin signal from another species, sharpening competition. A metabolic enzyme evolved into a signal reader, the team shows. That twist rewrites how this pathogen coordinates its virulence.
Catalog record
| CREATOR | Shihao Song, Jingyun Liu, Bing Wang, Yang Si, Hongguang Han, Xiuyun Sun, Mingfang Wang, Binbin Cui, Guangliang Wu, Yongliang Huo, Liangxiong Xu, Beile Gao, Liang Yang, Xiaoxue Wang, Lian‐Hui Zhang, Yinyue Deng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |