Dual glycosylation of wall teichoic acid modulates the O‐antigen pattern and virulence in serovar 4b Listeria monocytogenes
Hao Yao, Yuting Wang, Ruochen Wang, Zhengnan Dong, Zhenhua Wu, Luyong Wang, Yuelan Yin, Xin'an Jiao · 2025
Read Dual glycosylation of wall teichoic acid modulates the O‐antigen pattern and virulence in serovar 4b Listeria monocytogenes by Hao Yao, Yuting Wang, Ruochen Wang, Zhengnan Dong, Zhenhua Wu, Luyong Wang, Yuelan Yin, Xin'an Jiao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12754626.txt.
Description
Hao Yao and co-authors published a study in 2025 on a food-poisoning germ. One strain type of the germ causes most outbreaks in people. Its wall carries a sugar-coated acid layer dressed with two sugars. Much was known about one sugar; the pair's joint role was unclear.
The team found both sugars together form the surface pattern that immune tests read. One sugar alone serves as the hook for a virus that infects the germ. Together, the sugars boost surface film growth and shield the germ from a natural killer peptide. They also guide the anchoring of surface proteins and help the germ move inside host cells. In mice, the second sugar helped the germ colonize gut, liver, and brain. The authors say the pair explains the strain's high virulence.
Catalog record
| CREATOR | Hao Yao, Yuting Wang, Ruochen Wang, Zhengnan Dong, Zhenhua Wu, Luyong Wang, Yuelan Yin, Xin'an Jiao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |