Ferroptosis in human reproductive tract infections and associated disorders: mechanisms and emerging therapeutic opportunities
Xinchen Wan, Xue Wang, Yanjun Liu, Longyan Hong, Zhandi Zhao, Pengbo Guo · 2025
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Description
Xinchen Wan, Xue Wang, Yanjun Liu, Longyan Hong, Zhandi Zhao, and Pengbo Guo review a form of cell death in infections of the reproductive tract, in a 2025 paper. The death mode, ferroptosis, runs on iron and on the rust-like damage of cell fats. It ties to worn mitochondria, loss of a guard enzyme, and broken handling of iron and amino acids.
Infections of the reproductive system involve many germs and complex pathways, and ferroptosis now appears inside several of them. The review maps how the process drives harm in these infections and related disorders, including immune cell loss in HIV. It also surveys early ideas for drugs that block or harness the process. A fresh angle on stubborn infections could widen treatment choices.
Catalog record
| CREATOR | Xinchen Wan, Xue Wang, Yanjun Liu, Longyan Hong, Zhandi Zhao, Pengbo Guo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 108 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |