Identification of the Shared Gene Signatures and Pathways Between Polycystic Ovary Syndrome and Endometrial Cancer Using Bioinformatics and Mendelian Randomization Analyses
Dan Ye, Yi Yu, Chengjie Xu, Zhongpeng Fu, Fangfang Zhong, Haoran Shen · 2025
Read Identification of the Shared Gene Signatures and Pathways Between Polycystic Ovary Syndrome and Endometrial Cancer Using Bioinformatics and Mendelian Randomization Analyses by Dan Ye, Yi Yu, Chengjie Xu, Zhongpeng Fu, Fangfang Zhong, Haoran Shen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12753879.txt.
Description
Dan Ye and co-authors hunt for shared genes between two women's health disorders in a 2025 study. One is polycystic ovary syndrome, a common hormone disorder. The other is cancer of the womb lining. Women with the first face higher risk of the second. The team mined public gene data sets with network tools and gene-link tests.
Eight genes stood out in both disorders, among them MMP9, PECAM1, and CYBB. One shared path, type I interferon signaling, ranked as the key link. Gene-based cause tests also pointed to a true link between the two disorders, not just overlap. The authors say these genes and this path could serve as marks or drug aims that span both disorders. They note the work rests on data banks, so lab checks should follow.
Catalog record
| CREATOR | Dan Ye, Yi Yu, Chengjie Xu, Zhongpeng Fu, Fangfang Zhong, Haoran Shen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |