The study of the therapeutic effect and preliminary mechanism of EGCG on recurrent aphthous ulcer
XueDi You, JunXing Shi, ZhaoXu Ren, Li Wang, WanHong Zhao · 2025
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Description
XueDi You and four co-authors tested whether a green tea compound heals recurring mouth ulcers, in a 2025 paper. The compound, known as EGCG, is the main active part of green tea. The team created ulcers in mice with a chemical burn and treated them with the compound. They also used computer methods to predict which body targets the compound might act on.
Treated ulcers healed faster, and the mouth lining looked healthier under the microscope. Lab tests showed lower levels of two inflammatory signals in the tissue. A key inflammatory pathway, running through proteins TLR4 and NF-κB, was dialed down, more so at higher doses. Computer docking suggested the compound binds those proteins directly. The high-dose group did better than the group on a standard positive control. The authors conclude the compound aids healing by calming that pathway.
Catalog record
| CREATOR | XueDi You, JunXing Shi, ZhaoXu Ren, Li Wang, WanHong Zhao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |