Elemental and biomolecular changes in serum as indicators of SPION action in the body: analysis using TXRF, FTIR and Raman spectroscopy
Aleksandra Wilk, Karolina W. Lakomy, Zuzanna Setkowicz, Karol Szary, Regina Stachura, Katarzyna M. Marzec, Marzena Rugiel, Joanna Chwiej · 2025
Read Elemental and biomolecular changes in serum as indicators of SPION action in the body: analysis using TXRF, FTIR and Raman spectroscopy by Aleksandra Wilk, Karolina W. Lakomy, Zuzanna Setkowicz, Karol Szary, Regina Stachura, Katarzyna M. Marzec, Marzena Rugiel, Joanna Chwiej (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12753794.txt.
Description
Aleksandra Wilk and seven colleagues tracked how magnetic nanoparticles change rat blood over a week. They are superparamagnetic iron oxide particles. They are prized for imaging and therapy, but their effects on the body are not fully understood. That gap slows their move into clinic use. The team injected coated particles into male and female rats. The particles had magnetite cores ten nanometers wide. Blood serum was sampled at two hours, one day, and seven days.
Three light based methods profiled the serum. Two read the fingerprints of molecules, and one counted elements with great care. The infrared data showed shifts in the serum that grew over time. The changes hung on time and on sex, and point to sensitive signs of how particles act in the body. Knowing how the body registers these particles is groundwork for safe dosing in future imaging and therapy use.
Catalog record
| CREATOR | Aleksandra Wilk, Karolina W. Lakomy, Zuzanna Setkowicz, Karol Szary, Regina Stachura, Katarzyna M. Marzec, Marzena Rugiel, Joanna Chwiej |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |