Single-cell RNA transcriptomics divulged altered gene expressions in monocytes and HLA variations in decompensated cirrhosis patients with sepsis
Rashi Sehgal, Pramod Gautam, Mojahidul Islam, Jayesh Kumar Sevak, Maryam Javed, Navkiran Kaur, Gayatri Ramakrishna, Rakhi Maiwall, Shiv Kumar Sarin, Nirupama Trehanpati · 2025
Read Single-cell RNA transcriptomics divulged altered gene expressions in monocytes and HLA variations in decompensated cirrhosis patients with sepsis by Rashi Sehgal, Pramod Gautam, Mojahidul Islam, Jayesh Kumar Sevak, Maryam Javed, Navkiran Kaur, Gayatri Ramakrishna, Rakhi Maiwall, Shiv Kumar Sarin, Nirupama Trehanpati (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12753766.txt.
Description
Rashi Sehgal and co-authors present a 2025 study of blood cells from people with severe liver scarring, some of whom also had sepsis. In this state the immune system weakens fast, yet the cell changes are poorly known. The team read gene activity one cell at a time in patients and healthy controls.
They found ten cell clusters, with the monocyte group most varied. All patients shared some gene shifts, while those with sepsis showed weaker defense signals in one cell type. Certain HLA genes rose and others fell in sepsis. The maps may help doctors spot sepsis risk in these frail patients sooner.
Catalog record
| CREATOR | Rashi Sehgal, Pramod Gautam, Mojahidul Islam, Jayesh Kumar Sevak, Maryam Javed, Navkiran Kaur, Gayatri Ramakrishna, Rakhi Maiwall, Shiv Kumar Sarin, Nirupama Trehanpati |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |