Novel anti-ITGA4 monoclonal antibody induces cell death via large pore formation in NK/T-cell lymphoma cells
Shiori Takeuchi, Yasuhiko Ito, Shuji Matsuoka, Masaaki Abe, Hiromichi Tsurui, Yoshiya Horimoto, Takeshi Fukuhara, Takeshi Hirano, Natsuko Mizutani, Takumi Ito, Ryo Hatano, Atsuhito Nakao, Yasuhisa Terao, Mari Kitade, Yoshitomo Hamano, Hiroyuki Takamatsu, Hiroshi Matsuoka, Tetsuya Nakatsura, Hideo Ya · 2025
Read Novel anti-ITGA4 monoclonal antibody induces cell death via large pore formation in NK/T-cell lymphoma cells by Shiori Takeuchi, Yasuhiko Ito, Shuji Matsuoka, Masaaki Abe, Hiromichi Tsurui, Yoshiya Horimoto, Takeshi Fukuhara, Takeshi Hirano, Natsuko Mizutani, Takumi Ito, Ryo Hatano, Atsuhito Nakao, Yasuhisa Terao, Mari Kitade, Yoshitomo Hamano, Hiroyuki Takamatsu, Hiroshi Matsuoka, Tetsuya Nakatsura, Hideo Ya (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12753658.txt.
Description
Shiori Takeuchi and co-authors report, in a 2025 study, a new antibody that kills an aggressive lymphoma by punching large pores in its cells. Natural killer and T-cell lymphomas are fast and commoner in East Asia and Latin America. Fresh treatments are badly needed.
The team immunized mice with two lymphoma cell lines and screened the resulting antibodies on a third. One, named ANAP, killed cells immediately without help from complement or other immune cells. Its target is a surface adhesion protein. Death depended on the cell's internal skeleton and proceeded through pore formation. A directly lethal antibody sidesteps the resistance tricks tumors use against drugs that work through slower pathways.
Catalog record
| CREATOR | Shiori Takeuchi, Yasuhiko Ito, Shuji Matsuoka, Masaaki Abe, Hiromichi Tsurui, Yoshiya Horimoto, Takeshi Fukuhara, Takeshi Hirano, Natsuko Mizutani, Takumi Ito, Ryo Hatano, Atsuhito Nakao, Yasuhisa Terao, Mari Kitade, Yoshitomo Hamano, Hiroyuki Takamatsu, Hiroshi Matsuoka, Tetsuya Nakatsura, Hideo Ya |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |