Characterisation of human in vitro tumour-associated macrophage models to define translational relevance
Arthur Dyer, Rebecca Dudley, Shreya Ahuja, Clara Alsinet, Pawan Poudel, Georgina Bowyer, Kalvin Sahota, Saly Songvilay, Des C. Jones, Matthew Glover, Sonja Hess, Elina Timosenko, Simon J. Dovedi · 2025
Read Characterisation of human in vitro tumour-associated macrophage models to define translational relevance by Arthur Dyer, Rebecca Dudley, Shreya Ahuja, Clara Alsinet, Pawan Poudel, Georgina Bowyer, Kalvin Sahota, Saly Songvilay, Des C. Jones, Matthew Glover, Sonja Hess, Elina Timosenko, Simon J. Dovedi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12753636.txt.
Description
Arthur Dyer and a team of co-authors tested lab models of tumor-linked immune cells in a 2025 paper. Macrophages that live inside tumors can blunt the body's attack and weaken immunotherapy. The old habit of sorting them into two simple types no longer fits what doctors see in patients, so better dish models are needed.
The team bathed human macrophages in fluid from tumor cell lines and checked whether the cells turned suppressive and held back T cells. They profiled what the tumor fluid carried and how the macrophages changed, in both their proteins and gene activity. They also compared the models with fluid drawn from ovarian cancer patients. The work points to which dish setups best mirror real tumors.
Catalog record
| CREATOR | Arthur Dyer, Rebecca Dudley, Shreya Ahuja, Clara Alsinet, Pawan Poudel, Georgina Bowyer, Kalvin Sahota, Saly Songvilay, Des C. Jones, Matthew Glover, Sonja Hess, Elina Timosenko, Simon J. Dovedi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |