Colanic acid-mediated phage resistance enhances virulence in high-risk global clone Escherichia coli ST410
Jieying Tu, Jun Yang, Kewei Song, Jinghan Wang, Nuoyan Zhang, Wanyun He, Jinghao Liu, Zhongpeng Cai, Yuman Bai, Luchao Lv, Bingqing Zhu, Pan Tao, Jie Feng, Jian-Hua Liu · 2025
Read Colanic acid-mediated phage resistance enhances virulence in high-risk global clone Escherichia coli ST410 by Jieying Tu, Jun Yang, Kewei Song, Jinghan Wang, Nuoyan Zhang, Wanyun He, Jinghao Liu, Zhongpeng Cai, Yuman Bai, Luchao Lv, Bingqing Zhu, Pan Tao, Jie Feng, Jian-Hua Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12753057.txt.
Description
Jieying Tu and co-authors published a study in 2025 on how a drug-resistant gut bacterium dodges virus attack and grows more dangerous. The strain, known as ST410, spreads worldwide and resists many drugs. A virus that kills it was isolated, but resistance emerged fast in lab and animal tests. Beyond receptor changes, one mutant made excess colanic acid, a capsule sugar.
The capsule blocked a broad range of viruses, yet also helped the bacterium evade immune cells and killed mice faster. Gene data tied the change to a stress pathway. Like mutants appear among natural isolates. A planned four-virus mix restored strong killing in models. The authors warn phage therapy design must weigh this trade-off.
Catalog record
| CREATOR | Jieying Tu, Jun Yang, Kewei Song, Jinghan Wang, Nuoyan Zhang, Wanyun He, Jinghao Liu, Zhongpeng Cai, Yuman Bai, Luchao Lv, Bingqing Zhu, Pan Tao, Jie Feng, Jian-Hua Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |