The Effect of HIF‐2α on the Development of Inflammation
Jiarui Huang, Daohong Zhao · 2025
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Description
Jiarui Huang and Daohong Zhao published a 2025 review of a low-oxygen switch in the cell, HIF-2α, and its two-faced role in inflammation. The switch helps cells survive when oxygen runs low. Diseased and inflamed tissue is often low in oxygen, so the switch activates there. It tunes how immune cells work in that state.
The switch can feed inflammation or calm it. Which face shows depends on the cell type, the environment around it, and the pathways it activates. The review walks through the grip of the switch on each immune cell type, and the pathways by which it steers the growth of inflammation. It ends on the switch as a drug target: a way to tune inflammation by the oxygen state of the tissue.
Catalog record
| CREATOR | Jiarui Huang, Daohong Zhao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |