Exploratory Research on the Urine Proteome in Patients With Diabetic Peripheral Neuropathy
Lilong Wei, Yongwei Jiang, Haitong Wang, Jianqiang Wu, Chengwu Han, Yuliang Zhan, Yun Zhou, Yongtong Cao, Youhe Gao, Jaya Bharati · 2025
Read Exploratory Research on the Urine Proteome in Patients With Diabetic Peripheral Neuropathy by Lilong Wei, Yongwei Jiang, Haitong Wang, Jianqiang Wu, Chengwu Han, Yuliang Zhan, Yun Zhou, Yongtong Cao, Youhe Gao, Jaya Bharati (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12752815.txt.
Description
The authors present a 2025 exploratory study of proteins in urine as candidate markers for diabetic nerve damage. Diabetic peripheral neuropathy is common and disabling, yet clinicians have no blood or urine test for it. Urine is painless to collect and rich in shed proteins.
Mass spectrometry read urine from patients and healthy volunteers, finding 2,611 proteins, of which 1,759 could be measured reliably. Three hundred twelve differed strongly between groups, most of them reduced in patients. Random regrouping checks kept false discoveries in check, and clustering separated most samples by group alone. The changed proteins clustered in translation, secretion, protein folding, and immune response pathways. Some already have known links to diabetes. The authors offer the list as a starting map for marker hunting.
Catalog record
| CREATOR | Lilong Wei, Yongwei Jiang, Haitong Wang, Jianqiang Wu, Chengwu Han, Yuliang Zhan, Yun Zhou, Yongtong Cao, Youhe Gao, Jaya Bharati |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |