Interplay between aging and metabolic diseases: from molecular mechanisms to therapeutic horizons
Dandan Zhong, Yue Sun, Lanlan Zhao, Zhenchao Hu, Guanming Li, Hao Li, Zhengwei Xie · 2025
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Description
Dandan Zhong and co-authors review how aging and metabolic disease drive each other. Their twenty twenty-five paper maps a harmful cycle of decline that links the two. Old cells, faulty power plants in cells, and long-term swelling all play a part.
Other drivers include changed nutrient sensing, gene-control marks, broken daily rhythms, and gut microbe shifts. New treatments aim at this shared axis, from drugs that mimic fasting to ones that clear old cells. Multi-omics tools and gut-based care also show promise. The authors warn that tissue targeting and long-term safety still block wide clinical use.
Catalog record
| CREATOR | Dandan Zhong, Yue Sun, Lanlan Zhao, Zhenchao Hu, Guanming Li, Hao Li, Zhengwei Xie |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |