Effects of hypoxia and hyperoxia on exercise-induced metabolomic and transcriptomic profiles in equine skeletal muscle
Kenya Takahashi, Kazutaka Mukai, Yuji Takahashi, Yusaku Ebisuda, Fumi Sugiyama, Hideo Hatta, Yu Kitaoka · 2025
Read Effects of hypoxia and hyperoxia on exercise-induced metabolomic and transcriptomic profiles in equine skeletal muscle by Kenya Takahashi, Kazutaka Mukai, Yuji Takahashi, Yusaku Ebisuda, Fumi Sugiyama, Hideo Hatta, Yu Kitaoka (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12752499.txt.
Description
Kenya Takahashi and colleagues studied oxygen and exercise in Thoroughbred horses in 2025. Eight horses ran a short, hard effort under three air conditions. One condition gave normal oxygen. One gave extra oxygen, and one gave reduced oxygen. Blood oxygen levels rose or fell as expected. The team measured muscle chemicals and gene activity after exercise. They asked whether oxygen supply changes the muscle response to one hard bout.
Muscle fuel use looked much the same across conditions. Lactate and stored sugar showed no clear differences. Core energy pathways also responded alike. Gene activity told a different story. Fewer genes changed under extra or reduced oxygen than under normal air. Well-known exercise genes still responded in all conditions. Each oxygen level also switched on its own gene set. The authors say single-bout responses stay broadly stable. Oxygen-specific genes may still shape long-term training gains, they add.
Catalog record
| CREATOR | Kenya Takahashi, Kazutaka Mukai, Yuji Takahashi, Yusaku Ebisuda, Fumi Sugiyama, Hideo Hatta, Yu Kitaoka |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |