Ribosome-binding protein 1 maintains peroxisome biogenesis
Kaneez Fatima, Helena Vihinen, Ani Akpinar, Tamara Somborac, Anja Paatero, Eija Jokitalo, Ville Paavilainen, Pekka Katajisto, Svetlana Konovalova · 2024
Read Ribosome-binding protein 1 maintains peroxisome biogenesis by Kaneez Fatima, Helena Vihinen, Ani Akpinar, Tamara Somborac, Anja Paatero, Eija Jokitalo, Ville Paavilainen, Pekka Katajisto, Svetlana Konovalova (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12752496.txt.
Description
Kaneez Fatima and co-authors found an unexpected guardian of the cell's peroxisomes, in a study published in 2025. Peroxisomes are small organelles vital to health, yet how they are built stays partly mysterious. A systematic double screen in human cells flagged ribosome-binding protein 1, a protein of the protein-making machinery, as a new biogenesis factor.
Deleting it cut peroxisome counts and protein levels and garbled the finishing of key enzymes, while growth and translation carried on untouched. Without it, peroxisome proteins were shredded by the cell's disposal system instead of settling into membranes. The protein seems to shepherd new peroxisome parts into place. Organelle assembly gains a surprise cast member.
Catalog record
| CREATOR | Kaneez Fatima, Helena Vihinen, Ani Akpinar, Tamara Somborac, Anja Paatero, Eija Jokitalo, Ville Paavilainen, Pekka Katajisto, Svetlana Konovalova |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |