Disrupted genes and pathways in schizophrenia: a robust analysis of the brain and blood
Rebeca Rebouças, Mariana Araújo-Pereira, Tiago F. Mota, Henrique Q. S. Scoppetta, Moreno M. S. Rodrigues, Bruno B. Andrade, Eduardo R. Fukutani, Artur Trancoso Lopo de Queiroz · 2025
Read Disrupted genes and pathways in schizophrenia: a robust analysis of the brain and blood by Rebeca Rebouças, Mariana Araújo-Pereira, Tiago F. Mota, Henrique Q. S. Scoppetta, Moreno M. S. Rodrigues, Bruno B. Andrade, Eduardo R. Fukutani, Artur Trancoso Lopo de Queiroz (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12752432.txt.
Description
Rebeca Rebouças and co-authors hunt disrupted genes in schizophrenia across brain and blood in this 2025 paper. Schizophrenia scrambles thought, feeling, and behavior, but its biology stays murky. Shared gene signals in easy-to-sample blood would aid study and diagnosis.
The team pooled public gene expression sets from brain tissue and blood. A careful screen kept seventeen quality datasets from six sources. Comparing patients and controls gave 532 altered genes. A lean three-gene model then separated patients from controls with good accuracy. The trio held up in brain, whole blood, and immune cell sets. Pathway checks pointed toward nerve degeneration links worth deeper study.
Catalog record
| CREATOR | Rebeca Rebouças, Mariana Araújo-Pereira, Tiago F. Mota, Henrique Q. S. Scoppetta, Moreno M. S. Rodrigues, Bruno B. Andrade, Eduardo R. Fukutani, Artur Trancoso Lopo de Queiroz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |